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Color enhanced transmission electron micrograph (TEM) of avian influenza H5N1 grown in MDCK cells. Although this virus does not typically infect humans, in 1997, the first instance of direct bird-to-human spread of influenza A (H5N1) virus was documented during an outbreak of avian influenza among poultry in Hong Kong. The virus caused severe respiratory illness in 18 people, six of whom died. Colorized version of image number BD6167.